The Patriots and the Chiefs certainly had their hands full Sunday with previously unbeaten opponents, but they remain on an unbeaten collision course in the AFC.

The top two teams in The Post’s weekly NFL Power Rankings both went down to the closing seconds to record their respective fourth straight wins to open the season.

New England came up with a key defensive stand on Buffalo’s final drive, picking off Bills backup Matt Barkley with 1:27 remaining for a 16-10 win, improving to 4-0 for the fifth time in the Bill Belichick era.

Kansas City also remained perfect, with Patrick Mahomes leading a 78-yard drive for the go-ahead score with 20 seconds to go to hand the Lions (2-1-1) their first loss of the season, 34-30, in Detroit.

“It shows how you fight through the adversity,” said Mahomes, who didn’t throw any touchdown passes for only the third time in 21 regular-season NFL starts. “In this league, it’s not always going to be pretty. It’s not always going to be 50 points and three-touchdown wins. You have to find a way to win these games against great teams.

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