Lord & Taylor’s long goodbye to Fifth Avenue is about to begin — and it may include some nice deals on cashmere sweaters and designer handbags.

The upscale retailer’s 104-year-old flagship store at 424 Fifth Ave. — New York City’s oldest — is set to launch a final “store closing” sale on Thursday that will hawk deals on fashions and accessories throughout the holidays before the store shuts down for good.

The Grand Dame of Big Apple department stores, with its six huge sidewalk windows between 38th and 39th streets, had been perennially decked out during the Christmas season with spectacular displays for shoppers and tourists.

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